Drug reference
penicillin v
Penicillin (Natural) · Antibacterial, β-Lactam Antibiotic, Cell Wall Synthesis Inhibitor (Penicillin-susceptible infections)
Penicillin (Natural)Antibacterial, β-Lactam Antibiotic, Cell Wall Synthesis Inhibitor (Penicillin-susceptible infections)
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
B
FDA category + note
Mechanism
Penicillin V inhibits the last step in bacterial peptidoglycan synthesis by acylating the transpeptidase (penicillin-binding proteins, PBPs), which are crucial to the synthesis of the peptidoglycan layers of bacterial cell walls.
Indications
Respiratory diphtheria (following initial parenteral therapy)Cutaneous diphtheria (following initial parenteral therapy)
Pregnancy & lactation
Pregnancy
B
Related guidelines
Skin and soft tissue infections
IDSA · Infectious Diseases · 2010
Initial monotherapy for newly diagnosed epilepsy
ILAE · Neurology · 2013
Childhood pneumonia and respiratory infection
MOHFW · Paediatrics · 2021
Heart failure in diabetes
RSSDI · Cardiology · 2023
Initial monotherapy for newly diagnosed epilepsy
IAN · Neurology · 2023
Ask House about penicillin v
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Harrison 22e·Verified: 2026-05-10 · House clinical team