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perphenazine

first-generation antipsychotic · Antipsychotic

first-generation antipsychoticAntipsychotic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
C
FDA category + note
Top interactionssee all 12 →
  • AlfentanilSevereDatabaseDDInter
  • Aminolevulinic AcidSevereDatabaseDDInter
  • AmiodaroneSevereDatabaseDDInter
  • AmisulprideSevereDatabaseDDInter

Mechanism

Perphenazine is a D2 receptor antagonist.

Indications

Schizophreniaacute mania

Dosing

Adult
12–60 mg/day (oral)

Pharmacokinetics

Metabolism
CYP2D6

Contraindications

  • Use in elderly dementia patients (increased mortality risk)

Side effects

Common
Modest rates of EPSsakathisialimited anticholinergic side effectslimited sedationlimited weight gainlimited hypotension
Serious
  • Neuroleptic malignant syndrome
  • increased mortality in elderly dementia patients

Pregnancy & lactation

Pregnancy

C

Lactation

Not specified

Drug interactions

Alfentanil
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Aminolevulinic Acid
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Amiodarone
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Amisulpride
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Anagrelide
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Arsenic Trioxide
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Bedaquiline
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Benzhydrocodone
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Bepridil
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Buprenorphine
Severe
Database

Drug interaction classified as: synergy.

Source: DDInter

Bupropion
Severe
Database

Drug interaction classified as: metabolism.

Source: DDInter

Butorphanol
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Related guidelines

Schizophrenia
APA · Psychiatry · 2020
Schizophrenia
IPS · Psychiatry · 2017
Beta-blockers in hypertension
MOHFW · Cardiology · 2024
Gestational diabetes mellitus
FOGSI · Obstetrics & Gynaecology · 2023
Dyslipidaemia management
ICMR · Cardiology · 2023

Other first-generation antipsychotic drugs

thiothixene
0 brands

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team