Sulfonylureas
Severe
Textbook
Enhanced sulfonylurea action, potentially precipitating severe hypoglycaemia.
Monitor blood glucose closely and adjust sulfonylurea dosage as necessary.
Source: KDT 7e · p271
Drug reference
phenylbutazone
NSAID
NSAID
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- SulfonylureasSevereTextbookKDT 7e · p271
- AcalabrutinibSevereDatabaseDDInter
- ApixabanSevereDatabaseDDInter
- AvapritinibSevereDatabaseDDInter
Mechanism
Not yet extracted
Side effects
Serious
- fluid retention (accentuated in liver disease)
Drug interactions
Acalabrutinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Apixaban
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Avapritinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Betrixaban
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cabozantinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cidofovir
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cladribine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clozapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Dalteparin
Severe
Database
Clinical effect not specified
Source: DDInter
Dasatinib
Severe
Database
Clinical effect not specified
Source: DDInter
Deferasirox
Severe
Database
Clinical effect not specified
Source: DDInter
Other Unclassified drugs
Ask House about phenylbutazone
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team