Spironolactone
Contraindicated
Database
Life-threatening hyperkalemia, cardiac arrest.
Do not give potassium supplements with spironolactone unless closely monitored.
Source: DDInter
Drug reference
Potassium
Electrolyte · Electrolyte replacement
Also known as Potassium chloride
ElectrolyteElectrolyte replacement
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactionssee all 12 →
- SpironolactoneContraindicatedDatabaseDDInter
- AmilorideSevereDatabaseDDInter
- Azilsartan MedoxomilSevereDatabaseDDInter
- BenazeprilSevereDatabaseDDInter
Mechanism
Potassium is an essential intracellular cation critical for maintaining cell membrane potential, nerve impulse transmission, and muscle contraction, including that of the heart. It plays a vital role in regulating fluid balance and electrolyte homeostasis, particularly influenced by kidney function. Certain potassium channels, such as Kv7/KCNQ, serve as molecular targets for various pharmacological agents.
Indications
Electrolyte replacementManagement of conditions requiring potassium supplementation (e.g., hypokalemia)
Dosing
- Adult
- volume (e.g. 24–48 mL) of sodium chloride intravenous. of infusion over a short period of time, e.g. 100 mL in
Contraindications
- Hyperkalemia
- Chronic kidney disease (patients on low-potassium diet)
Side effects
Serious
- Serious cardiac effects (especially with improper administration or hyperkalemia)
Drug interactions
Amiloride
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Azilsartan Medoxomil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Benazepril
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Captopril
Severe
Database
Drug interaction classified as: synergy.
Source: DDInter
Enalapril
Severe
Database
Hyperkalemia.
Avoid K+ supplements with ACEi unless hypokalemic.
Source: DDInter
Eplerenone
Severe
Database
Hyperkalemia.
Avoid K+ supplements.
Source: DDInter
Eprosartan
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Fosinopril
Severe
Database
.
Source: DDInter
Irbesartan
Severe
Database
.
Source: DDInter
Lisinopril
Severe
Database
.
Source: DDInter
Losartan
Severe
Database
Hyperkalemia: muscle weakness, paresthesias, cardiac arrhythmias.
Monitor serum potassium. Avoid routine potassium supplementation with ARBs
Source: DDInter
Related guidelines
Fluid and electrolyte management in diabetes
RSSDI · Endocrinology · 2025
Gastric premalignant conditions
ACG · Gastroenterology · 2025
Iron deficiency anaemia in pregnancy
ICMR · Obstetrics & Gynaecology · 2022
Iron deficiency anaemia in adults
ICMR · Hematology · 2023
Infant and child nutrition
ICMR · Pediatrics · 2024
Other Electrolyte drugs
Ask House about Potassium
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: BNF·Verified: 2026-05-10 · House clinical team