Drug reference

rabies immune globulin

Immunoglobulin · Immunizing agent

ImmunoglobulinImmunizing agent

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Provides immediate, passive immunity by supplying pre-formed neutralizing antibodies against rabies virus, bridging the gap until the recipient's active immune response to rabies vaccine develops.

Indications

Passive immunization for postexposure prophylaxis (PEP) of rabies in previously unvaccinated persons.

Dosing

Adult: 20 IU/kg. The entire dose, if anatomically feasible, should be infiltrated at the site of the bite. Any remaining after infiltration should be administered IM at a distant site. With multiple or large wounds, dilution may be needed. If exposure involves a mucous membrane, the entire dose should be administered IM.
Pediatric: 20 IU/kg, administered as per adult guidelines.