Ozanimod
Severe
Textbook
Serious hypertensive interactions.
Avoid combining ozanimod with SNRIs due to the potential for serious hypertensive interactions.
Source: G&G 14e · p1119
Drug reference
Reboxetine
SNRI · Antidepressant
Also known as Reboxetine mesilate
SNRIAntidepressant
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
3 major
SEVERE in our sources
PREGNANCY
Use only if potential benefit outweighs risk—limited information available.
FDA category + note
Top interactions
- OzanimodSevereTextbookG&G 14e · p1119
- TapentadolSevereTextbookG&G 14e · p462
- TramadolSevereTextbookG&G 14e · p462
Mechanism
Reboxetine is a selective inhibitor of noradrenaline re-uptake. Inhibition of reuptake enhances neurotransmission by slowing clearance of the transmitter from the synapse and prolonging its dwell-time. This mechanism is presumed to lead to adaptive changes in monoamine systems.
Indications
Major depression
Dosing
- Adult
- BY MOUTH: 4 mg twice daily for 3–4 weeks, then increased if necessary to 10 mg daily in divided doses.
- Renal adjustment
- Initial dose 2 mg twice daily, increased according to tolerance.
- Hepatic adjustment
- Initial dose reduction to 2 mg twice daily, increased according to tolerance.
- Max dose
- 12 mg per day
Contraindications
- Bipolar disorder
- History of cardiovascular disease
- History of epilepsy
- Prostatic hypertrophy
- Susceptibility to angle-closure glaucoma
- Urinary retention
Side effects
Common
Accommodation disorderAkathisiaAnxietyAppetite decreasedChillsConstipationDizzinessDry mouthHeadacheHyperhidrosisHypertensionHypotensionInsomniaNauseaPalpitationsParaesthesiaSexual dysfunctionSkin reactionsTachycardiaTaste alteredUrinary disordersUrinary tract infectionVasodilationVomitingMydriasisVertigo
Serious
- Glaucoma
- Aggression
- Hallucination
- Hyponatraemia
- Irritability
- Peripheral coldness
- Potassium depletion (long term use)
- Raynaud’s phenomenon
- Suicidal tendencies
- Testicular pain
Pregnancy & lactation
Pregnancy
Use only if potential benefit outweighs risk—limited information available.
Lactation
Small amount present in milk—use only if potential benefit outweighs risk.
Drug interactions
Tapentadol
Severe
Textbook
Risk of serotonin syndrome.
Monitor closely for signs of serotonin syndrome. Avoid co-administration if possible.
Source: G&G 14e · p462
Tramadol
Severe
Textbook
Can cause serotonin syndrome.
Tramadol should not be used in patients taking SNRIs.
Source: G&G 14e · p462
Related guidelines
Ask House about Reboxetine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Katzung, BNF·Verified: 2026-05-10 · House clinical team