Drug reference

rofecoxib

COX-2 inhibitor (coxib) · Anti-inflammatory, Analgesic

COX-2 inhibitor (coxib)Anti-inflammatory, Analgesic

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

12 major

incl. contraindicated

PREGNANCY

—

not curated

Top interactionssee all 12 →

Other Nsaids (non Selective Or Other Cox 2 Inhibitors)ContraindicatedDatabase
CidofovirSevereDatabaseDDInter
DeferasiroxSevereDatabaseDDInter
DiatrizoateSevereDatabaseDDInter

Mechanism

Selectively inhibits cyclooxygenase-2 (COX-2).

Contraindications

Withdrawn from market due to cardiovascular risk profile

Side effects

Serious

Increased incidence of myocardial infarction
Increased incidence of stroke
Increased incidence of vascular death
Cardiovascular risk

Drug interactions

Other Nsaids (non Selective Or Other Cox 2 Inhibitors)

Contraindicated

Database

Significantly increased risk of serious gastrointestinal adverse events (ulcers, bleeding, perforation) and renal impairment without additional therapeutic benefit.

Concomitant use is contraindicated. Avoid using rofecoxib with any other NSAID, including other COX-2 selective inhibitors.

Cidofovir

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Deferasirox

Severe

Database

Clinical effect not specified

Source: DDInter

Diatrizoate

Severe

Database

Clinical effect not specified

Source: DDInter

Everolimus

Severe

Database

Clinical effect not specified

Source: DDInter

Human Cytomegalovirus Immune Globulin

Severe

Database

Clinical effect not specified

Source: DDInter

Inotersen

Severe

Database

Clinical effect not specified

Source: DDInter

Iohexol

Severe

Database

Clinical effect not specified

Source: DDInter

Iopamidol

Severe

Database

Clinical effect not specified

Source: DDInter

Iopromide

Severe

Database

Clinical effect not specified

Source: DDInter

Iothalamic Acid

Severe

Database

Clinical effect not specified

Source: DDInter

Ioversol

Severe

Database

Clinical effect not specified

Source: DDInter

Related guidelines

Inflammatory bowel disease

OTHER · Gastroenterology · 2015

Preventive care in inflammatory bowel disease

ACG · Gastroenterology · 2025

Heart failure in diabetes

RSSDI · Cardiology · 2023

Hypertension in adults

ICMR · Cardiology · 2019

Hypertrophic cardiomyopathy

ESC · Cardiology · 2026

Other COX-2 inhibitor (coxib) drugs

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team