Drug reference

selinexor

exportin 1 (XPO1) inhibitor · Antineoplastic agent

exportin 1 (XPO1) inhibitorAntineoplastic agent

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

12 major

SEVERE in our sources

PREGNANCY

FDA category + note

Top interactionssee all 12 →

AdalimumabSevereDatabaseDDInter
BaricitinibSevereDatabaseDDInter
CertolizumabSevereDatabaseDDInter
CladribineSevereDatabaseDDInter

Mechanism

Selinexor is an orally bioavailable reversible inhibitor of exportin 1 (XPO1).

Indications

MM who have received at least one prior therapy (in combination with bortezomib and dexamethasone)relapsed or refractory diffuse large B-cell lymphoma after at least two lines of systemic therapyRelapsed multiple myeloma

Pharmacokinetics

Half-life

6 to 8 h (elimination)

Metabolism

CYP3A4

Side effects

Common

fatiguenauseavomitingdecreased appetitediarrheaperipheral neuropathyupper respiratory tract infectiondecreased weightcataract

Serious

thrombocytopenia
neutropenia
hyponatremia
infection

Pregnancy & lactation

Pregnancy

Drug interactions

Adalimumab

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Baricitinib

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Certolizumab

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Cladribine

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Clozapine

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Deferiprone

Severe

Database

Clinical effect not specified

Source: DDInter

Etanercept

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Fingolimod

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Golimumab

Severe

Database

Clinical effect not specified

Source: DDInter

Infliximab

Severe

Database

Clinical effect not specified

Source: DDInter

Leflunomide

Severe

Database

Clinical effect not specified

Source: DDInter

Measles Virus Vaccine Live Attenuated

Severe

Database

Clinical effect not specified

Source: DDInter

Related guidelines

Hypertension in adults

ICMR · Cardiology · 2019

Heart failure in diabetes

RSSDI · Cardiology · 2023

Systemic lupus erythematosus

EULAR · Rheumatology · 2023

Hypertrophic cardiomyopathy

ESC · Cardiology · 2026

Sjögren's syndrome

EULAR · Rheumatology · 2025

Ask House about selinexor

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Sources: Goodman & Gilman 14e, Harrison 22e·Verified: 2026-05-10 · House clinical team