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selumetinib

MEK inhibitor, kinase inhibitor · antineoplastic, targeted therapy

MEK inhibitor, kinase inhibitorantineoplastic, targeted therapy
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
D
FDA category + note
Top interactionssee all 12 →
  • AmprenavirSevereDatabaseDDInter
  • ApalutamideSevereDatabaseDDInter
  • AprepitantSevereDatabaseDDInter
  • AtazanavirSevereDatabaseDDInter

Mechanism

MEK inhibitor.

Indications

redifferentiation therapy (with or without BRAF inhibition) to induce radioiodine uptake in non–iodine-avid thyroid cancerspediatric patients with neurofibromatosis type 1 and inoperable, plexiform neurofibromas

Pharmacokinetics

Half-life
6.2 h (elimination)
Metabolism
CYP3A4 (primarily)

Side effects

Common
vomiting (>40%)rash (>40%)abdominal pain (>40%)
Serious
  • cardiomyopathy
  • ocular toxicity
  • skin toxicity
  • GI toxicity

Pregnancy & lactation

Pregnancy

D

Drug interactions

Amprenavir
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Apalutamide
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Aprepitant
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Atazanavir
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Boceprevir
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Bosentan
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Carbamazepine
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Cenobamate
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Ceritinib
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Chloramphenicol
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Ciprofloxacin
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Clarithromycin
Severe
Database

Drug interaction classified as: metabolism

Source: DDInter

Related guidelines

Hypothyroidism in adults
ITS · Endocrinology · 2021
Hypothyroidism in adults
ENDOCRINE_SOCIETY · Endocrinology · 2014
Heart failure in diabetes
RSSDI · Cardiology · 2023
Fluid and electrolyte management in diabetes
RSSDI · Endocrinology · 2025
Infant and child nutrition
ICMR · Pediatrics · 2024

Other MEK inhibitor, kinase inhibitor drugs

trametinib
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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team