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Drug reference

solriamfetol

Wake-promoting agent

Wake-promoting agent
CDSCO approved
EXCRETION
not curated
INTERACTIONS
10 major
SEVERE in our sources
PREGNANCY
not curated
Top interactionssee all 10
  • IsocarboxazidSevereDatabaseDDInter
  • LinezolidSevereDatabaseDDInter
  • Methylene BlueSevereDatabaseDDInter
  • OzanimodSevereDatabaseDDInter

Mechanism

Norepinephrine–dopamine reuptake inhibitor.

Indications

NarcolepsyExcessive sleepiness during night work (Shift-Work Disorder)

Drug interactions

Isocarboxazid
Severe
Database

Clinical effect not specified

Source: DDInter

Linezolid
Severe
Database

Clinical effect not specified

Source: DDInter

Methylene Blue
Severe
Database

Clinical effect not specified

Source: DDInter

Ozanimod
Severe
Database

Clinical effect not specified

Source: DDInter

Phenelzine
Severe
Database

Clinical effect not specified

Source: DDInter

Procarbazine
Severe
Database

Clinical effect not specified

Source: DDInter

Rasagiline
Severe
Database

Clinical effect not specified

Source: DDInter

Safinamide
Severe
Database

Clinical effect not specified

Source: DDInter

Selegiline
Severe
Database

Clinical effect not specified

Source: DDInter

Tranylcypromine
Severe
Database

Clinical effect not specified

Source: DDInter

2 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.

Related guidelines

Other Unclassified drugs

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Sources: Harrison 22e·Verified: 2026-05-10 · House clinical team