Drug reference

Somatostatin

Somatostatin Analogue · Antisecretory

Somatostatin AnalogueAntisecretory

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Somatostatin is a neuroactive peptide that may play a role in the transmission of afferent impulses from autonomic structures. Its analogues are often used to reduce gastric acid secretion, which often increases stoma output. They are also more effective than bromocriptine in inhibiting growth hormone release, for example in acromegaly.

Indications

Gastric acid hypersecretion leading to increased stoma output (managed by analogues)Acromegaly (managed by analogues)Controlling bleeding esophageal varicesControlling bleeding peptic ulcerPancreatic fistulaeBiliary fistulaeIntestinal fistulaeAdjuvant value in diabetic ketoacidosisAcromegaly (limited use)

Dosing

Adult: high doses of loperamide hydrochloride may be required. Codeine phosphate can be added if response with loperamide hydrochloride alone is inadequate. Digoxin Patients with a stoma are particularly susceptible to hypokalaemia if taking digoxin p. 116, due to ﬂuid and sodium depletion. Potassium supplements or a potassiumsparing diuretic may be advisable with monitoring for early signs of toxicity.…