Aminobenzoic Acid
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
sulfisoxazole
Sulfonamide · Antibacterial, Antiprotozoal (in combination)
SulfonamideAntibacterial, Antiprotozoal (in combination)
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
9 major
SEVERE in our sources
PREGNANCY
D
FDA category + note
Top interactionssee all 9 →
- Aminobenzoic AcidSevereDatabaseDDInter
- Aminolevulinic AcidSevereDatabaseDDInter
- CyclosporineSevereDatabaseDDInter
- LomitapideSevereDatabaseDDInter
Mechanism
Not yet extracted
Indications
Cystitis (where resistance prevalence is not high)Toxoplasmosis (in combination with pyrimethamine, alternative to TMP-SMX for Nocardia spp.)Otitis media (in children, as sulfisoxazole acetyl in combination with erythromycin ethylsuccinate)
Pharmacokinetics
Peak effect
2 to 4 h
Protein binding
Extensive binding to plasma proteins (approximately 30% acetylated form in blood)
Side effects
Common
NauseaVomitingAnorexiaHypersensitivity reactions (allergy usually associated with sulfonamide moiety)Gastrointestinal effects
Serious
- Nephrotoxicity
- Hematologic effects (leukopenia, thrombocytopenia, granulocytopenia)
- Risk in third trimester of pregnancy
Pregnancy & lactation
Pregnancy
D
Drug interactions
Aminolevulinic Acid
Severe
Database
Clinical effect not specified
Source: DDInter
Cyclosporine
Severe
Database
Clinical effect not specified
Source: DDInter
Lomitapide
Severe
Database
Clinical effect not specified
Source: DDInter
Methenamine
Severe
Database
Clinical effect not specified
Source: DDInter
Mipomersen
Severe
Database
Clinical effect not specified
Source: DDInter
Nitrous Acid
Severe
Database
Clinical effect not specified
Source: DDInter
Pexidartinib
Severe
Database
Clinical effect not specified
Source: DDInter
Warfarin
Severe
Database
Clinical effect not specified
Source: DDInter
3 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Antimicrobial resistance — clinical roadmap
MOHFW · Infectious Diseases · 2012
Acute diarrhoea in children
IAP · Pediatrics · 2022
Acute calculous cholecystitis
WSES · Surgery · 2020
Drug-resistant tuberculosis
RNTCP · Pulmonology · 2025
Empirical antimicrobial use in common syndromes
ICMR · Infectious Diseases · 2019
Other Sulfonamide drugs
Ask House about sulfisoxazole
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Harrison 22e·Verified: 2026-05-10 · House clinical team