Chlorthalidone
Severe
Textbook-cited
Increased incidence of thrombocytopenia
Avoid concurrent use
Source: KDT 7e · p948
Drug reference
sulfonamides
Bacteriostatic agents
Bacteriostatic agents
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- ChlorthalidoneSevereTextbook-citedKDT 7e · p948
- DesogestrelSevereTextbook-citedKDT 7e · p948
- EthinylestradiolSevereTextbook-citedKDT 7e · p948
- GlibenclamideSevereTextbook-citedKDT 7e · p948
Mechanism
Sulfonamides are transformed into hydroxylamines that interact with cellular proteins, generating haptens that can elicit autoimmune responses.
Pharmacokinetics
Metabolism
Sulfonamides undergo acetylation.
Excretion
Sulfonamides are excreted directly in the colon.
Contraindications
- Slow acetylator phenotype (predisposed to autoimmune responses and hypersensitivity reactions)
- Potentially nephrotoxic (due to crystalluria)
Side effects
Common
chronic and low grade phototoxic photosensitivityphotoallergic photosensitivity
Serious
- Idiosyncratic hypersensitivity reactions
- haemolysis (in G-6PD deficient individuals)
Drug interactions
Desogestrel
Severe
Textbook-cited
Contraceptive failure
Advise alternative contraception
Source: KDT 7e · p948
Ethinylestradiol
Severe
Textbook-cited
Contraceptive failure
Advise alternative contraception
Source: KDT 7e · p948
Glibenclamide
Severe
Textbook-cited
Hypoglycemia
Avoid concurrent use; if needed, monitor blood glucose closely
Source: KDT 7e · p948
Gliclazide
Severe
Textbook-cited
Hypoglycemia
Avoid concurrent use; if needed, monitor blood glucose closely
Source: KDT 7e · p948
Glimepiride
Severe
Textbook-cited
Hypoglycemia
Avoid concurrent use; if needed, monitor blood glucose closely
Source: KDT 7e · p948
Glipizide
Severe
Textbook-cited
Hypoglycemia
Avoid concurrent use; if needed, monitor blood glucose closely
Source: KDT 7e · p948
Hydrochlorothiazide
Severe
Textbook-cited
Increased incidence of thrombocytopenia
Avoid concurrent use
Source: KDT 7e · p948
Indapamide
Severe
Textbook-cited
Increased incidence of thrombocytopenia
Avoid concurrent use
Source: KDT 7e · p948
Levonorgestrel
Severe
Textbook-cited
Contraceptive failure
Advise alternative contraception
Source: KDT 7e · p948
Norethisterone
Severe
Textbook-cited
Contraceptive failure
Advise alternative contraception
Source: KDT 7e · p948
Phenytoin
Severe
Textbook-cited
Phenytoin toxicity (nystagmus, ataxia, sedation)
Avoid concurrent use; if unavoidable, monitor phenytoin levels
Source: KDT 7e · p948
Other Unclassified drugs
Ask House about sulfonamides
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Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team