Cimetidine
Severe
Textbook
Enhanced sulfonylurea action, potentially precipitating severe hypoglycaemia.
Monitor blood glucose closely and adjust sulfonylurea dosage as necessary.
Source: KDT 7e · p271
Drug reference
sulfonylureas
Drug monograph
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- CimetidineSevereTextbookKDT 7e · p271
- KetoconazoleSevereTextbookKDT 7e · p271
- LithiumSevereTextbookKDT 7e · p271
- PhenylbutazoneSevereTextbookKDT 7e · p271
Mechanism
Not yet extracted
Side effects
Common
photoallergic photosensitivity
Drug interactions
Ketoconazole
Severe
Textbook
Enhanced sulfonylurea action, potentially precipitating severe hypoglycaemia.
Monitor blood glucose closely and adjust sulfonylurea dosage as necessary.
Source: KDT 7e · p271
Lithium
Severe
Textbook
Enhanced sulfonylurea action, potentially precipitating severe hypoglycaemia.
Monitor blood glucose closely and adjust sulfonylurea dosage as necessary.
Source: KDT 7e · p271
Phenylbutazone
Severe
Textbook
Enhanced sulfonylurea action, potentially precipitating severe hypoglycaemia.
Monitor blood glucose closely and adjust sulfonylurea dosage as necessary.
Source: KDT 7e · p271
Sulfinpyrazone
Severe
Textbook
Enhanced sulfonylurea action, potentially precipitating severe hypoglycaemia.
Monitor blood glucose closely and adjust sulfonylurea dosage as necessary.
Source: KDT 7e · p271
Sympatholytic Antihypertensives
Severe
Textbook
Enhanced sulfonylurea action, potentially precipitating severe hypoglycaemia.
Monitor blood glucose closely and adjust sulfonylurea dosage as necessary.
Source: KDT 7e · p271
Theophylline
Severe
Textbook
Enhanced sulfonylurea action, potentially precipitating severe hypoglycaemia.
Monitor blood glucose closely and adjust sulfonylurea dosage as necessary.
Source: KDT 7e · p271
Warfarin
Severe
Textbook
Enhanced sulfonylurea action, potentially precipitating severe hypoglycaemia.
Monitor blood glucose closely and adjust sulfonylurea dosage as necessary.
Source: KDT 7e · p271
Fluconazole
Severe
Database
Fluconazole inhibits CYP2C9-mediated metabolism of sulfonylureas, causing prolonged hypoglycemia. One fatality reported with glyburide + fluconazole.
Monitor blood glucose closely; reduce sulfonylurea dose by 50%. Consider switching to non-sulfonylurea hypoglycemic. Hypoglycemia may persist 4-5 days after fluconazole discontinuation due to long t½.
Source: Kimi deep-research + Cla · p793
Insulin Detemir
Severe
Database
Additive glucose lowering
Reduce doses; monitor glucose closely
Source: Kimi deep-research + Cla
Linagliptin
Severe
Database
Additive hypoglycaemia
Reduce sulfonylurea/insulin dose; monitor glucose
Source: Kimi deep-research + Cla
Voriconazole
Severe
Database
Voriconazole inhibits CYP2C9, increasing sulfonylurea levels and causing severe hypoglycemia.
Monitor blood glucose closely; reduce sulfonylurea dose by 50%.
Source: Kimi deep-research + Cla
Other Unclassified drugs
Ask House about sulfonylureas
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team