Bupropion
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
tacrine
Noncovalent cholinesterase inhibitor · Cognition Enhancer (for Alzheimer's disease)
Noncovalent cholinesterase inhibitorCognition Enhancer (for Alzheimer's disease)
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- BupropionSevereDatabaseDDInter
- IohexolSevereDatabaseDDInter
- IopamidolSevereDatabaseDDInter
- LeflunomideSevereDatabaseDDInter
Mechanism
Tacrine reversibly inhibits acetylcholinesterase (AChE) by binding with higher affinity to the active center gorge, sterically blocking acetylcholine from entering for catalysis. It has a prolonged duration of action.
Indications
alzheimer’s disease (now in disuse)
Pharmacokinetics
Bioavailability
Well absorbed after oral administration
Protein binding
Partitioning into lipid
Metabolism
Hepatic (implied by hepatotoxicity)
Side effects
Serious
- hepatotoxicity
Drug interactions
Iohexol
Severe
Database
Clinical effect not specified
Source: DDInter
Iopamidol
Severe
Database
Clinical effect not specified
Source: DDInter
Leflunomide
Severe
Database
Clinical effect not specified
Source: DDInter
Lomitapide
Severe
Database
Clinical effect not specified
Source: DDInter
Mipomersen
Severe
Database
Clinical effect not specified
Source: DDInter
Ozanimod
Severe
Database
Clinical effect not specified
Source: DDInter
Pexidartinib
Severe
Database
Clinical effect not specified
Source: DDInter
Siponimod
Severe
Database
Clinical effect not specified
Source: DDInter
Teriflunomide
Severe
Database
Clinical effect not specified
Source: DDInter
Tizanidine
Severe
Database
Clinical effect not specified
Source: DDInter
Tramadol
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Coeliac disease
OTHER · Gastroenterology · 2016
Inflammatory bowel disease
OTHER · Gastroenterology · 2015
Chronic kidney disease — assessment and management
KDIGO · Nephrology · 2024
Chronic kidney disease — assessment and management
NICE · Nephrology · 2021
Diabetes management in chronic kidney disease
KDIGO · Nephrology · 2022
Other Noncovalent cholinesterase inhibitor drugs
Ask House about tacrine
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team