Siponimod
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
edrophonium
Noncovalent cholinesterase inhibitor · Diagnostic Agent; Antiarrhythmic (supraventricular tachycardia)
Noncovalent cholinesterase inhibitorDiagnostic Agent; Antiarrhythmic (supraventricular tachycardia)
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
1 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactions
- SiponimodSevereDatabaseDDInter
Mechanism
Edrophonium, a quaternary cation, reversibly binds to the choline subsite in the active center of acetylcholinesterase (AChE). This noncovalent association sterically blocks acetylcholine from entering the active site for catalysis.
Indications
antagonize the action of nondepolarizing muscle relaxantsdiagnosis of myasthenia gravis
Pharmacokinetics
Duration
Brief duration of action
Excretion
Rapid renal elimination
Drug interactions
11 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Other Noncovalent cholinesterase inhibitor drugs
Ask House about edrophonium
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team