Drug reference

Telbivudine

Antimetabolite · Antiviral for Chronic Hepatitis B

AntimetaboliteAntiviral for Chronic Hepatitis B

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

1 major

SEVERE in our sources

PREGNANCY

(see Useful

FDA category + note

Top interactions

Interferon AlfaSevereDatabaseDDInter

Mechanism

Telbivudine, as an oral nucleoside/nucleotide analog, is used to treat chronic hepatitis B virus infection and is thought to inhibit the HBV DNA polymerase, interfering with viral replication.

Indications

Chronic hepatitis BChronic HBV in adult patients (≥16 years) with evidence of viral replication and persistent elevations in serum aminotransferases or histologically active disease (alternative agent)Indefinite treatment for patients with cirrhosis

Dosing

Adult: is given by mouth for the treatment of chronic hepatitis C infection, in double therapy with peginterferon alfa, interferon alfa, or sofosbuvir, or in triple therapy with peginterferon alfa and one protease inhibitor or sofosbuvir. Ribavirin is also effective in Lassa fever [unlicensed indication].…
Renal adjustment: Requires dose adjustments for moderate-to-severe renal dysfunction and hemodialysis patients