Drug reference

temsirolimus

mTOR inhibitor · Antineoplastic

mTOR inhibitorAntineoplastic

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

12 major

SEVERE in our sources

PREGNANCY

FDA category + note

Top interactionssee all 12 →

AcyclovirSevereDatabaseDDInter
AdalimumabSevereDatabaseDDInter
AmikacinSevereDatabaseDDInter
Amphotericin BSevereDatabaseDDInter

Mechanism

Not yet extracted

Indications

advanced renal cell carcinoma

Dosing

Adult: weekly intravenous administration

Pharmacokinetics

Half-life

30 h (parent drug), 53 h (sirolimus, active metabolite)

Bioavailability

—

Protein binding

—

Metabolism

Pharmacokinetics distinct from sirolimus and everolimus

Excretion

4.6%

Side effects

Common

hyperlipidemiaanemialeukopeniathrombocytopeniagi effectsmouth ulcershyperkalemiamild maculopapular rashmucositisfatigue (30%–50%)hyperglycemiahypertriglyceridemia

Serious

leukopenia
thrombocytopenia
pulmonary infiltrates
interstitial lung disease

Pregnancy & lactation

Pregnancy

Drug interactions

Acyclovir

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Adalimumab

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Amikacin

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Amphotericin B

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Amprenavir

Severe

Database

Drug interaction classified as: metabolism

Source: DDInter

Anisindione

Severe

Database

Drug interaction classified as: others

Source: DDInter

Antithrombin Iii Human

Severe

Database

Drug interaction classified as: others

Source: DDInter

Apalutamide

Severe

Database

Drug interaction classified as: metabolism

Source: DDInter

Apixaban

Severe

Database

Drug interaction classified as: others

Source: DDInter

Ardeparin

Severe

Database

Drug interaction classified as: others

Source: DDInter

Argatroban

Severe

Database

Drug interaction classified as: others

Source: DDInter

Atazanavir

Severe

Database

Drug interaction classified as: metabolism

Source: DDInter

Related guidelines

Coronary angiography with renal dysfunction

CSI · Cardiology · 2020

Heart failure in diabetes

RSSDI · Cardiology · 2023

Acute kidney injury

KDIGO · Nephrology · 2012

Chronic kidney disease — assessment and management

KDIGO · Nephrology · 2024

Hypertension in adults

ICMR · Cardiology · 2019

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team