Adalimumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
Teniposide
Topoisomerase Inhibitor · Antineoplastic
Topoisomerase InhibitorAntineoplasticATC null
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
X
FDA category + note
Top interactionssee all 12 →
- AdalimumabSevereDatabaseDDInter
- BaricitinibSevereDatabaseDDInter
- CertolizumabSevereDatabaseDDInter
- CladribineSevereDatabaseDDInter
Mechanism
Teniposide is an epipodophyllotoxin that inhibits DNA synthesis. It acts by damaging DNA, with its toxicity being greatest during the S-phase of the cell cycle.
Indications
Acute lymphoblastic leukemia in childrenRefractory acute lymphoblastic leukemia (ALL) in childrenAcute leukemia in childrenMonocytic leukemia in infantsGlioblastomaNeuroblastomaBrain metastases from small cell carcinomas of the lung
Dosing
- Adult
- Dosage need not be reduced for patients with impaired renal function.
Pharmacokinetics
Half-life
Multiphasic pattern of clearance: 4 h (after distribution), and another of 10 to 40 h.
Metabolism
Metabolized by CYP3A4/3A5/3A7 enzymes. Transport is influenced by P-glycoprotein (ABCB1).
Excretion
Approximately 45% of the drug is excreted in the urine; as much as 80% is recovered as metabolites.
Side effects
Common
MyelosuppressionNauseaVomiting
Pregnancy & lactation
Pregnancy
X
Drug interactions
Baricitinib
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Certolizumab
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cladribine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Clozapine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Deferiprone
Severe
Database
Clinical effect not specified
Source: DDInter
Etanercept
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Fingolimod
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Golimumab
Severe
Database
Clinical effect not specified
Source: DDInter
Infliximab
Severe
Database
Clinical effect not specified
Source: DDInter
Leflunomide
Severe
Database
Clinical effect not specified
Source: DDInter
Measles Virus Vaccine Live Attenuated
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Topoisomerase Inhibitor drugs
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Textbook-sourced·Sources: Goodman & Gilman 14e, Katzung·Updated: 2026-05-10