Sodium Oxybate
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
Terazosin
Alpha Blocker · Antihypertensive, Benign Prostatic Hyperplasia Agent
Also known as Terazosin hydrochloride
Alpha BlockerAntihypertensive, Benign Prostatic Hyperplasia AgentATC C02CA04
CDSCO approvedSchedule HATC C02CA04
EXCRETION
—
not curated
INTERACTIONS
2 major
SEVERE in our sources
PREGNANCY
Manufacturer advises avoid—no information available.
FDA category + note
Top interactionssee all 12 →
- Sodium OxybateSevereDatabaseDDInter
- TizanidineSevereDatabaseDDInter
Mechanism
Terazosin possesses alpha-blocking and vasodilator properties, similar to prazosin. As an alpha1-selective adrenoceptor blocker, it relaxes smooth muscle in benign prostatic hyperplasia, leading to an increase in urinary flow-rate and an improvement in obstructive symptoms.
Indications
Resistant hypertensionBenign prostatic hyperplasiaUrinary retention due to benign prostatic hyperplasiahypertensionbenign prostatic hyperplasia (BPH)Hypertension (not as monotherapy)Benign hypertrophy of prostate (BHP)
Dosing
- Adult
- reduce blood pressure rapidly after the first dose and should be introduced with caution. Doxazosin, indoramin p. 827, and terazosin have properties similar to those of prazosin. Hypertension 155 Alpha-blockers can be used with other antihypertensive drugs in the treatment of resistant hypertension. . receiving high-dose vasodilator therapy; . known renovascular disease.…
Pharmacokinetics
Duration
usually extends beyond 18 h
Half-life
about 12 h
Bioavailability
high (>90%)
Protein binding
90–94%
Excretion
about 10% excreted unchanged in urine
Contraindications
- Heart failure
Side effects
Common
DizzinessFatigueSweatingPostural hypotensionFirst-dose phenomenonPalpitationNasal blockageMiosisInhibition of ejaculation
Serious
- Collapse due to hypotensive effect
- postural hypotension (first-dose effect)
- Increased risk for developing congestive heart failure
Pregnancy & lactation
Pregnancy
Manufacturer advises avoid—no information available.
Lactation
Manufacturer advises avoid; gastrointestinal disturbances in infant reported.
Drug interactions
Tizanidine
Severe
Database
.
Source: DDInter
Bucindolol
Moderate
Textbook
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: G&G 14e
Celiprolol
Moderate
Textbook
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: G&G 14e
Acebutolol
Moderate
Database
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: DDInter
Atenolol
Moderate
Database
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: DDInter
Betaxolol
Moderate
Database
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: DDInter
Bisoprolol
Moderate
Database
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: DDInter
Carteolol
Moderate
Database
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: DDInter
Carvedilol
Moderate
Database
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: DDInter
Esmolol
Moderate
Database
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: DDInter
Labetalol
Moderate
Database
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: DDInter
Related guidelines
Other Alpha Blocker drugs
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Textbook-sourced·Sources: KD Tripathi 7e, Goodman & Gilman 14e, BNF·Updated: 2026-05-13