Acebutolol
Moderate
Textbook
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: G&G 14e
Drug reference
Indoramin
Alpha Blocker · Antihypertensive
Also known as Indoramin hydrochloride
Alpha BlockerAntihypertensive
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
No evidence of teratogenicity; manufacturers advise use only when potential benefit outweighs risk.
FDA category + note
Mechanism
Indoramin is an alpha-1 selective adrenergic receptor antagonist. It blocks alpha-1 adrenergic receptors, inhibiting vasoconstriction induced by endogenous catecholamines. This leads to vasodilation in both arteriolar resistance vessels and veins, resulting in a fall in blood pressure due to decreased peripheral resistance.
Indications
HypertensionBenign prostatic hyperplasiaCongestive heart failure (rarely used)benign prostatic hyperplasia (BPH)prophylaxis of migraineRaynaud syndrome (decreases incidence of attacks)
Dosing
- Adult
- Hypertension: Initially 500 micrograms 2-3 times a day for 3-7 days (initial dose at night to avoid collapse), increased to 1 mg 2-3 times a day for a further 3-7 days, then increased if necessary up to 20 mg daily in divided doses.…
- Renal adjustment
- Manufacturer advises caution.
- Hepatic adjustment
- Manufacturer advises caution.
- Geriatric
- For benign prostatic hyperplasia, 20 mg daily may be adequate, dose to be taken at night. Potentially inappropriate for alpha-1 selective adrenoceptor blockers in those with symptomatic orthostatic hypotension, micturition syncope, or persistent postural hypotension.
- Max dose
- 20 mg daily for hypertension; 100 mg daily for benign prostatic hyperplasia; 200 mg daily for congestive heart failure.
Contraindications
- Heart failure (before initiating)
- Epilepsy
- History of depression
- Parkinson's disease
- Symptomatic orthostatic hypotension (in elderly)
- Micturition syncope (in elderly)
- Persistent postural hypotension (in elderly)
Side effects
Common
Depressiondizzinessdrowsinessdry mouthejaculation failurefatigueheadachenasal congestionweight increasedsedationfailure of ejaculation
Serious
- Parkinson’s disease exacerbated
- Extrapyramidal disorders
- Convulsions
- Orthostatic hypotension (risk of syncope and falls)
- Micturition syncope (risk of recurrent syncope)
Pregnancy & lactation
Pregnancy
No evidence of teratogenicity; manufacturers advise use only when potential benefit outweighs risk.
Lactation
No information available.
Drug interactions
Atenolol
Moderate
Textbook
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: G&G 14e
Betaxolol
Moderate
Textbook
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: G&G 14e
Bisoprolol
Moderate
Textbook
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: G&G 14e
Bucindolol
Moderate
Textbook
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: G&G 14e
Carteolol
Moderate
Textbook
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: G&G 14e
Carvedilol
Moderate
Textbook
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: G&G 14e
Celiprolol
Moderate
Textbook
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: G&G 14e
Esmolol Hydrochloride
Moderate
Textbook
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: G&G 14e
Esmolol
Moderate
Textbook
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: G&G 14e
Labetalol
Moderate
Textbook
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: G&G 14e
Levobunolol
Moderate
Textbook
Increased antihypertensive effect.
This combination is often used to achieve better blood pressure control and manage reflex tachycardia from alpha-1 blockers.
Source: G&G 14e
Related guidelines
Other Alpha Blocker drugs
Ask House about Indoramin
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Katzung, BNF·Verified: 2026-05-13 · House clinical team