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teriflunomide

Pyrimidine-synthesis inhibitor · Immunomodulator

Pyrimidine-synthesis inhibitorImmunomodulator
CDSCO approved
EXCRETION
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
not curated
Top interactionssee all 12
  • AbacavirSevereDatabaseDDInter
  • AbataceptSevereDatabaseDDInter
  • AbemaciclibSevereDatabaseDDInter
  • AbirateroneSevereDatabaseDDInter

Mechanism

Reduces pyrimidine synthesis by reversibly inhibiting dihydro-orotate dehydrogenase, thereby causing a reduction in proliferation of activated B and T cells.

Indications

relapsing-remitting ms

Side effects

Serious
  • hepatotoxicity

Drug interactions

Abacavir
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Abatacept
Severe
Database

Drug interaction classified as: others

Source: DDInter

Abemaciclib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Abiraterone
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Acalabrutinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Acarbose
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Acitretin
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Adalimumab
Severe
Database

Drug interaction classified as: others

Source: DDInter

Afatinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Aflibercept
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Aldesleukin
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Alectinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Related guidelines

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team