Drug reference

tetracyclines

Antibiotic (implied by context of drug interactions and absorption characteristics and common knowledge of drug class but not explicitly stated for this drug in the text itself)

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

6 major

incl. contraindicated

PREGNANCY

—

not curated

Top interactionssee all 12 →

AminophyllineContraindicatedTextbookKDT 7e · p227
HeparinContraindicatedTextbookKDT 7e · p58
IsotretinoinContraindicatedDatabaseKimi deep-research + Cla
Long Term UseSevereTextbookKDT 7e · p894

Mechanism

Not yet extracted

Indications

Chronic, difficult-to-treat intestinal amoebiasis (adjuvant role with luminal amoebicide)Amoebic dysentery (as third drug with nitroimidazole + luminal amoebicide)

Dosing

Adult: 250 mg TDS for 7–10 days (as adjuvant).

Contraindications

Accentuate uraemia (due to anti-anabolic effect)
Potentially nephrotoxic (except doxycycline)

Side effects

Common

toxicity on bone and teeth

Serious

deposits in growing teeth causing discoloration/deformation
renal tubular damage resembling Fanconi syndrome (from outdated capsules)
discoloured and deformed teeth (teratogenic)
retarded bone growth (teratogenic)
superinfections (secondary effect due to suppression of bacterial flora)
phototoxic photosensitivity

Drug interactions

Aminophylline

Contraindicated

Textbook

Should not be mixed in the same infusion bottle/syringe.

Do not mix.

Source: KDT 7e · p227

Heparin

Contraindicated

Textbook

Incompatibility and potential loss of drug effect.

Do not mix in the same syringe/infusion bottle.

Source: KDT 7e · p58

Isotretinoin

Contraindicated

Database

Both isotretinoin and tetracyclines can increase intracranial pressure. Combined use significantly increases risk of pseudotumor cerebri (benign intracranial hypertension) with headache, nausea, vomiting, papilledema, and vision loss.

Absolute contraindication. Do NOT use tetracyclines during isotretinoin therapy. Use alternative antibiotics (macrolides) if needed for acne.

Source: Kimi deep-research + Cla

Long Term Use

Severe

Textbook

Intracranial hypertension.

Caution is advised with long-term systemic antibiotic therapy due to potential complications.

Source: KDT 7e · p894

Calcium Carbonate

Severe

Database

Chelation → markedly reduced antibiotic absorption/efficacy

Separate by ≥2–4 h

Source: Kimi deep-research + Cla

Sucralfate

Severe

Database

Aluminum in sucralfate chelates tetracyclines, reducing absorption by 50-80% and causing treatment failure.

Separate administration by at least 2 hours. Give tetracycline 1 hour before or 2 hours after sucralfate.

Source: Kimi deep-research + Cla · p656

Aluminum

Moderate

Textbook

Poor absorption of tetracycline.

Avoid concurrent ingestion. Dairy products, antacids, aluminum hydroxide gels; calcium, magnesium, iron, or zinc salts; bismuth subsalicylate; and dietary iron and zinc supplements can interfere with absorption of tetracyclines. Omadacycline specifically requires administration on an empty stomach, at least 4 hours after and 2 hours before food consumption. Food, including dairy products, does not interfere with absorption of doxycycline and minocycline but significantly impairs the absorption of omadacycline.

Source: G&G 14e · p1181

Antacids Or Drugs Containing Calcium Magnesium Iron Or Aluminum

Moderate

Textbook

Decreased oral absorption of tetracyclines.

Administer tetracycline 2 h before or 6 h after interacting drug.

Source: Harrison 22e · p1172

Antacids

Moderate

Textbook

Reduced absorption of tetracyclines.

Administer the two drugs at 2–3 hour intervals.