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thiopentone

Anaesthetic (i.v.) hypnotic action via redistribution from brain to less perfused tissues with high lipid-solubility characteristics of the drug itself and subsequent distribution to less vascular but

Anaesthetic (i.v.) hypnotic action via redistribution from brain to less perfused tissues with high lipid-solubility characteristics of the drug itself and subsequent distribution to less vascular but
CDSCO approved
EXCRETION
not curated
INTERACTIONS
none in our sources
PREGNANCY
C
FDA category + note

Mechanism

Not yet extracted

Indications

anaesthesia

Pharmacokinetics

Onset
Practically instantaneous
Duration
few minutes (due to redistribution)
Half-life
9 hours
Protein binding
75%
Metabolism
Redistribution (termination of action after i.v. injection)

Pregnancy & lactation

Pregnancy

C

Drug interactions

Succinylcholine
Moderate
Textbook

Chemical incompatibility, leading to potential loss of drug efficacy or unpredictable effects.

These drugs should not be mixed in the same syringe.

Source: KDT 7e · p382

Related guidelines

Other Unclassified drugs

Ask House about thiopentone

Continue into a citation-backed clinical answer with the drug context already attached.

Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team