Dinoprostone
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
urea
Osmotic Diuretic · Diuretic
Osmotic DiureticDiuretic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
1 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactions
- DinoprostoneSevereDatabaseDDInter
Mechanism
Urea acts as a nonreabsorbable solute in the proximal tubule and loop of Henle. It limits the osmosis of water into the interstitial space, reducing luminal Na+ concentration and ceasing net Na+ reabsorption. By extracting water from intracellular compartments, it expands extracellular fluid volume and reduces medullary tonicity, which diminishes passive NaCl reabsorption in the ATL.
Indications
dialysis disequilibrium syndromecontrol intraocular pressure (acute attacks, preoperatively, postoperatively in ocular surgery)reduce cerebral edemareduce brain mass (before and after neurosurgery, in traumatic brain injury)Hyperkeratinized lesions (e.g., ichthyosis, lichen planus)
Dosing
- Adult
- 5–20% in cream/ointment base
Pharmacokinetics
Half-life
1.2
Bioavailability
Negligible (oral)
Excretion
renal excretion of intact drug
Contraindications
- anuric due to severe renal disease
- impaired liver function (risk of elevated blood ammonia levels)
- active cranial bleeding
- heart failure
- pulmonary congestion
Side effects
Common
headachenauseavomiting
Serious
- pulmonary edema (in heart failure or pulmonary congestion)
- hyponatremia
- hypernatremia
- dehydration
- thrombosis (if extravasation occurs)
- pain (if extravasation occurs)
Drug interactions
11 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Dialysis — initiation and maintenance
ISN_INDIA · Nephrology · 2023
Empirical antimicrobial use in common syndromes
ICMR · Infectious Diseases · 2019
Acute kidney injury
KDIGO · Nephrology · 2012
Acute coronary syndrome in chronic kidney disease
CSI · Cardiology · 2020
Preoperative cardiac evaluation for non-cardiac surgery
AHA · Cardiology · 2025
Other Osmotic Diuretic drugs
Ask House about urea
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team