Urokinase

The fibrinolytic system dissolves intravascular fibrin through the action of plasmin. Plasminogen activators convert single-chain plasminogen into two-chain plasmin by cleavage of a specific peptide bond. Urokinase is a plasminogen activator (u-PA) that promotes extravascular fibrinolysis by converting plasminogen into plasmin, which then degrades fibrin clots.

Adult

Deep-vein thrombosis (thromboembolic occlusive vascular disease): By intravenous infusion, initially 4400 units/kg over 10–20 minutes, followed by 100 000 units/hour for 2–3 days. For SYNER-KINASE®, by intravenous infusion, initially 4400 units/kg over 10 minutes (made up in 15 mL sodium chloride 0.9%), followed by 4400 units/kg/hour for 12–24 hours.…

Renal adjustment

Dose reduction may be required.

Hepatic adjustment

Manufacturer advises caution in mild to moderate impairment; consider dose reduction.

Max dose

For pulmonary embolism (SYNER-KINASE®, intra-arterial injection): maximum 3 doses per day.