Drug reference directory
Drug reference

valnoctamide

Tranquilizer

Tranquilizer
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated

Mechanism

Valnoctamide inhibits microsomal epoxide hydrolase (mEH).

Drug interactions

Carbamazepine
Moderate
Textbook

Elevation in plasma concentrations of the active carbamazepine-10,11-epoxide metabolite and consequent side effects.

This interaction has led to efforts to develop new antiepileptic drugs (e.g., gabapentin, levetiracetam) that are metabolized by CYPs and not by EHs.

Source: G&G 14e · p107

Other Unclassified drugs

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Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10