Antacids
Moderate
Textbook
Reduced plasma levels and potential loss of efficacy of baloxavir.
Avoid taking baloxavir with antacids.
Source: Harrison 22e · unknown
Drug reference
baloxavir
Antiviral agent for influenza (cap-dependent endonuclease inhibitor)
Antiviral agent for influenza (cap-dependent endonuclease inhibitor)
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Baloxavir inhibits the cap-dependent endonuclease that is important in initiating synthesis of influenza virus mRNA.
Drug interactions
Calcium Containing Oral Supplements
Moderate
Textbook
Reduced plasma levels and potential loss of efficacy of baloxavir.
Avoid taking baloxavir with oral supplements containing calcium.
Source: Harrison 22e · unknown
Dairy Products
Moderate
Textbook
Reduced plasma levels and potential loss of efficacy of baloxavir.
Avoid taking baloxavir with dairy products.
Source: Harrison 22e · unknown
Iron Containing Oral Supplements
Moderate
Textbook
Reduced plasma levels and potential loss of efficacy of baloxavir.
Avoid taking baloxavir with oral supplements containing iron.
Source: Harrison 22e · unknown
Magnesium Containing Oral Supplements
Moderate
Textbook
Reduced plasma levels and potential loss of efficacy of baloxavir.
Avoid taking baloxavir with oral supplements containing magnesium.
Source: Harrison 22e · unknown
Polyvalent Cation Containing Laxatives
Moderate
Textbook
Reduced plasma levels and potential loss of efficacy of baloxavir.
Avoid taking baloxavir with polyvalent cation-containing laxatives.
Source: Harrison 22e · unknown
Selenium Containing Oral Supplements
Moderate
Textbook
Reduced plasma levels and potential loss of efficacy of baloxavir.
Avoid taking baloxavir with oral supplements containing selenium.
Source: Harrison 22e · unknown
Zinc Containing Oral Supplements
Moderate
Textbook
Reduced plasma levels and potential loss of efficacy of baloxavir.
Avoid taking baloxavir with oral supplements containing zinc.
Source: Harrison 22e · unknown
Related guidelines
Other Unclassified drugs
Ask House about baloxavir
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Sources: Harrison 22e·Verified: 2026-05-10 · House clinical team