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Drug reference

belinostat

HDAC inhibitor · Antineoplastic agent

HDAC inhibitorAntineoplastic agent
CDSCO approved
EXCRETION
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
D
FDA category + note
Top interactionssee all 12
  • AdalimumabSevereDatabaseDDInter
  • BaricitinibSevereDatabaseDDInter
  • CertolizumabSevereDatabaseDDInter
  • CladribineSevereDatabaseDDInter

Mechanism

Belinostat is an HDAC inhibitor. Inhibition of HDAC activity causes the accumulation of acetyl groups on histone lysine residues, an open chromatin structure, and activation of target genes that are selectively repressed in tumors.

Indications

peripheral T-cell lymphoma

Side effects

Serious
  • hematological toxicity
  • infections
  • hepatotoxicity

Pregnancy & lactation

Pregnancy

D

Drug interactions

Adalimumab
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Baricitinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Certolizumab
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Cladribine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Clozapine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Deferiprone
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Etanercept
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Fingolimod
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Golimumab
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Infliximab
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Leflunomide
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Lomitapide
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Related guidelines

Other HDAC inhibitor drugs

Ask House about belinostat

Continue into a citation-backed clinical answer with the drug context already attached.

Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team