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romidepsin

HDAC inhibitor · Antineoplastic agent

HDAC inhibitorAntineoplastic agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
D
FDA category + note
Top interactionssee all 12 →
  • AdalimumabSevereDatabaseDDInter
  • AmiodaroneSevereDatabaseDDInter
  • AmisulprideSevereDatabaseDDInter
  • AnagrelideSevereDatabaseDDInter

Mechanism

Romidepsin functions as a prodrug. Within cells, a zinc-binding thiol of the drug is reduced and interacts with a zinc atom in the binding pocket of HDAC to block its activity. Inhibition of HDAC activity causes the accumulation of acetyl groups on histone lysine residues, an open chromatin structure, and activation of target genes that are selectively repressed in tumors.

Indications

cutaneous T-cell lymphoma

Pharmacokinetics

Half-life
about 3 h (terminal)
Metabolism
CYP3A4 (major after intravenous administration)

Side effects

Common
nauseavomitinganemiathrombocytopenialeukopeniaabnormal electrolyte levelsECG changes

Pregnancy & lactation

Pregnancy

D

Drug interactions

Adalimumab
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Amiodarone
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Amisulpride
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Anagrelide
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Arsenic Trioxide
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Baricitinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Bedaquiline
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Bepridil
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Cabozantinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Ceritinib
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Certolizumab
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Chloroquine
Severe
Database

Drug interaction classified as: synergy

Source: DDInter

Related guidelines

Heart failure in diabetes
RSSDI · Cardiology · 2023
Hypertension in adults
ICMR · Cardiology · 2019
Primary PCI for acute coronary syndrome
ESC · Cardiology · 2026
Hypertrophic cardiomyopathy
ESC · Cardiology · 2026
Diabetes management in chronic kidney disease
KDIGO · Nephrology · 2022

Other HDAC inhibitor drugs

belinostat
0 brands
vorinostat
0 brands

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team