Alfentanil
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
butabarbital
Barbiturate · Hypnotic
BarbiturateHypnotic
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AlfentanilSevereDatabaseDDInter
- AnisindioneSevereDatabaseDDInter
- BenzhydrocodoneSevereDatabaseDDInter
- BuprenorphineSevereDatabaseDDInter
Mechanism
Barbiturates enhance GABA-mediated inhibitory transmission throughout the CNS. They bind to an allosteric site on the GABAA receptor, increasing the mean open time of the GABA-activated Cl– channel. At higher concentrations, barbiturates directly activate channel opening.
Indications
InsomniaPreoperative sedationDaytime sedation
Pharmacokinetics
Half-life
35–50
Drug interactions
Anisindione
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Benzhydrocodone
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Buprenorphine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Butorphanol
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Codeine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Dextropropoxyphene
Severe
Database
Drug interaction classified as: synergy, metabolism
Source: DDInter
Dezocine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Dicoumarol
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Dihydrocodeine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Ethanol
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Fentanyl
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Related guidelines
Other Barbiturate drugs
Ask House about butabarbital
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team