Drug reference

Clomiphene

Aromatase Inhibitor · Treatment of infertility

Also known as Clomifene citrate, CLOMID, SEROPHENE, Milophene

Aromatase InhibitorTreatment of infertility

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

Possible effects on fetal development; exclude pregnancy before treatment.

FDA category + note

Mechanism

Clomiphene is classified as an anti-estrogen, acting as a pure antagonist at estrogen receptors in all tissues studied. This antagonism disrupts the negative feedback of estrogen on the hypothalamus and pituitary gland. Consequently, it leads to increased secretion of gonadotropins, which stimulates ovulation in anovulatory women.

Indications

Treatment of infertility in anovulatory womentreatment of infertility in anovulatory women (with functional hypothalamic-hypophyseal-ovarian system and adequate endogenous estrogen production)polycystic ovary syndrome (PCOS)dysfunctional bleeding with anovulatory cyclesinduction of superovulation (in women with unexplained infertility)

Dosing

Adult: gel | 15 unit dose P £30.83 DT = £30.83 Capsule EXCIPIENTS: May contain Arachis (peanut) oil ▶ Utrogestan (Besins Healthcare (UK) Ltd) Progesterone 100 mg Utrogestan 100mg capsules | 30 capsule P £5.13 DT = £5.13 Progesterone 200 mg Utrogestan 200mg vaginal capsules with applicators | 21 capsule P £21.00 DT = £21.00 8.1a Anti-oestrogens OVULATION STIMULANTS Clomifene citrate 20-Nov-2019 (Clomiphen…

Pharmacokinetics

Half-life

5–7 days (long plasma t1/2 due to plasma-protein binding, enterohepatic circulation, and accumulation in fatty tissues)

Excretion

primarily in the feces, to a lesser extent in the urine

Contraindications

Pregnancy
Liver disease or history of liver dysfunction
Uterine fibroids

Side effects

Common

Abdominal distensionAlopeciaAngioedemaAnxietyBreast tendernessDepressionDisorientationDizzinessFatigueHeadacheHot flushHypertriglyceridaemiaInsomniaMenstrual cycle irregularitiesMood alteredNauseaPalpitationsParaesthesiaSkin reactionsSpeech disorderSyncopeTachycardiaUterine disordersVertigoVomitingovarian hyperstimulationincreased incidence of multiple birthsovarian cystshot flashesblurred vision

Serious