Drug reference

Clomifene citrate

Aromatase Inhibitor · Ovulation Stimulant

Also known as Clomiphene citrate, Clomid

Aromatase InhibitorOvulation Stimulant

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Clomifene citrate is an anti-oestrogen that induces gonadotrophin release by occupying oestrogen receptors in the hypothalamus, thereby interfering with feedback mechanisms. This action leads to an elevation of serum LH.

Indications

Female infertility due to ovulatory dysfunction

Dosing

Adult: Adult (female): 50 mg once daily by mouth for 5 days, initiated at any time if no recent uterine bleeding, or on or around the fifth day of cycle if progestogen-induced bleeding is planned or spontaneous uterine bleeding occurs. If ovulation does not occur, a second course of 100 mg once daily for 5 days may be given, at least 30 days after the first course.…
Max dose: 100 mg once daily for 5 days per course; long-term cyclical therapy not recommended beyond a total of 6 cycles.

Contraindications

Abnormal uterine bleeding of undetermined cause
Hormone-dependent tumours
Ovarian cysts
Long-term cyclical therapy beyond 6 cycles (due to possible increased risk of ovarian cancer)