Tizanidine
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
Diazoxide
Antidote · Antihypoglycemic agent
Also known as Eudemine, Proglycem
AntidoteAntihypoglycemic agent
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
1 major
SEVERE in our sources
PREGNANCY
Use only if essential; alopecia and hypertrichosis reported in neonates with prolonged use; may inhibit uterine activity during labour.
FDA category + note
Top interactionssee all 11 →
- TizanidineSevereDatabaseDDInter
Mechanism
Diazoxide is classified as a glycogenolytic hormone. It is used to manage chronic intractable hypoglycaemia by increasing blood glucose levels.
Indications
Chronic intractable hypoglycaemiaInoperable insulinomasNeonatal hyperinsulinismHypertensive crisisprevent hypoglycaemia in insulinomasRapid reduction of BP in hypertensive emergencies
Dosing
- Adult
- Initially 5 mg/kg daily in 2–3 divided doses, adjusted according to response; maintenance 3–8 mg/kg daily in 2–3 divided doses by mouth.
- Renal adjustment
- Dose reduction may be required.
Pharmacokinetics
Half-life
48 h
Protein binding
Largely bound to plasma proteins
Side effects
Common
Abdominal painAlbuminuriaAppetite decreased (long term use)ConstipationDiarrhoeaDizzinessDyspnoeaFeverFluid retentionHeadacheHirsutismHyperglycaemiaHyperuricaemia (long term use)HypotensionMusculoskeletal painNauseaSkin reactionsSodium retentionTaste alteredTinnitusVision disordersVoice alteration (long term use)VomitingRetention of Na+ and fluidHyperuricemiaHypertrichosisvasodilatationfall in blood pressureantidiuresis
Serious
- Arrhythmia
- Azotaemia
- Cardiomegaly
- Cataract
- Diabetic hyperosmolar coma
- Eosinophilia
- Extrapyramidal symptoms
- Galactorrhoea
- Haemorrhage
- Heart failure
- Hypogammaglobulinaemia
- Ileus
- Ketoacidosis
- Leucopenia
- Libido decreased
- Nephritic syndrome
- Oculogyric crisis
- Pancreatitis
- Parkinsonism
- Pulmonary hypertension
- Thrombocytopenia
- Leukopenia
Pregnancy & lactation
Pregnancy
Use only if essential; alopecia and hypertrichosis reported in neonates with prolonged use; may inhibit uterine activity during labour.
Lactation
Manufacturer advises avoid—no information available.
Drug interactions
Sulfonylureas
Moderate
Textbook
Reduced glucose-lowering effect of sulfonylureas.
Source: G&G 14e · p1034
Xipamide
Moderate
Textbook
Enhanced diazoxide effects.
Not explicitly stated, but implies caution during coadministration.
Source: G&G 14e · p567
Bendroflumethiazide
Moderate
Database
Enhanced diazoxide effects.
Not explicitly stated, but implies caution during coadministration.
Source: DDInter
Chlorthalidone
Moderate
Database
Enhanced diazoxide effects.
Not explicitly stated, but implies caution during coadministration.
Source: DDInter
Hydralazine
Moderate
Database
Profound additive hypotension
Avoid concurrent use
Source: Kimi deep-research + Cla
Hydrochlorothiazide
Moderate
Database
Enhanced diazoxide effects.
Not explicitly stated, but implies caution during coadministration.
Source: DDInter
Hydroflumethiazide
Moderate
Database
Enhanced diazoxide effects.
Not explicitly stated, but implies caution during coadministration.
Source: DDInter
Indapamide
Moderate
Database
Enhanced diazoxide effects.
Not explicitly stated, but implies caution during coadministration.
Source: DDInter
Metolazone
Moderate
Database
Enhanced diazoxide effects.
Not explicitly stated, but implies caution during coadministration.
Source: DDInter
Trichlormethiazide
Moderate
Database
Enhanced diazoxide effects.
Not explicitly stated, but implies caution during coadministration.
Source: DDInter
1 additional low-confidence interaction hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Hypertensive disorders of pregnancy
FOGSI · Obstetrics & Gynaecology · 2019
Preventive care in inflammatory bowel disease
ACG · Gastroenterology · 2025
Stroke and TIA — secondary prevention
AHA · Neurology · 2021
Neonatal infection
NICE · Neonatology · 2021
Tobacco-related cancer prevention
ICMR · Oncology · 2021
Other Antidote drugs
Ask House about Diazoxide
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Katzung, BNF·Verified: 2026-05-10 · House clinical team