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Dimercaprol

Antidote · Antidote for Heavy Metal Poisoning, Anti-thyroid Agent

Also known as BAL

AntidoteAntidote for Heavy Metal Poisoning, Anti-thyroid Agent
CDSCO approvedSchedule H
EXCRETION
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
not curated
Top interactionssee all 12
  • Ferric CarboxymaltoseSevereDatabaseDDInter
  • Ferric DerisomaltoseSevereDatabaseDDInter
  • Ferrous FumarateSevereDatabaseDDInter
  • Ferrous GluconateSevereDatabaseDDInter

Mechanism

Dimercaprol acts as a chelating agent, forming stable complexes with metals, typically as five- or six-membered rings. This chelation prevents or reverses metal binding to biological ligands, facilitating their removal from the body. Additionally, dimercaprol has been observed to possess anti-thyroid activity, similar to thioureylene drugs, by interfering with iodine incorporation into thyroglobulin and inhibiting iodotyrosyl coupling.

Indications

Lead poisoningMercury poisoningArsenic poisoningHeavy metal poisoning (note: largely superseded by other chelating agents)Anti-thyroid activity (observed effect)

Dosing

Adult
Heavy metal poisoning: 3-5 mg/kg IM every 4-6 hours.

Drug interactions

Ferric Carboxymaltose
Severe
Database

Clinical effect not specified

Source: DDInter

Ferric Derisomaltose
Severe
Database

Clinical effect not specified

Source: DDInter

Ferrous Fumarate
Severe
Database

Clinical effect not specified

Source: DDInter

Ferrous Gluconate
Severe
Database

Clinical effect not specified

Source: DDInter

Ferrous Sulfate Anhydrous
Severe
Database

Clinical effect not specified

Source: DDInter

Ferumoxides
Severe
Database

Clinical effect not specified

Source: DDInter

Ferumoxsil
Severe
Database

Clinical effect not specified

Source: DDInter

Ferumoxytol
Severe
Database

Clinical effect not specified

Source: DDInter

Iron
Severe
Database

Clinical effect not specified

Source: DDInter

Iron Dextran
Severe
Database

Clinical effect not specified

Source: DDInter

Iron Protein Succinylate
Severe
Database

Clinical effect not specified

Source: DDInter

Selenium
Severe
Database

Clinical effect not specified

Source: DDInter

Related guidelines

Other Antidote drugs

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Sources: KD Tripathi 7e, Katzung·Verified: 2026-05-10 · House clinical team