Drug reference

Digoxin Immune Fab

Antidote · Treatment of Digoxin Toxicity

Also known as Digoxin-specific antibody fragments, DigiFab, Digibind

AntidoteTreatment of Digoxin Toxicity

CDSCO approvedSchedule H

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Digoxin immune Fab fragments bind to free digoxin or digitoxin in the blood, creating an inactive complex. This binding effectively removes the cardiac glycoside from its site of action on Na+,K+-ATPase, reversing the toxic effects. The Fab-digoxin complex is then renally excreted, enhancing the elimination of the drug.

Indications

Treatment of known or strongly suspected life-threatening digoxin toxicity associated with ventricular arrhythmias or bradyarrhythmias unresponsive to atropine and when measures beyond the withdrawal of digoxin and correction of any electrolyte abnormalities are considered necessaryLife-threatening digitoxin toxicitySerious arrhythmias due to cardiac glycoside intoxication

Dosing

Adult: followed by careful control of the hypertension. She was initially treated with a diuretic (furosemide, 40 mg twice daily). On this therapy, she was less short of breath on exertion and could also lie flat without dyspnea. An angiotensinconverting enzyme (ACE) inhibitor was added (enalapril, 20 mg twice daily), and over the next few weeks, she continued to feel better.…