Burosumab
Severe
Database
Clinical effect not specified
Source: DDInter
Drug reference
Dihydrotachysterol
Vitamin · Agent for hypoparathyroidism
Also known as DHT
VitaminAgent for hypoparathyroidism
CDSCO approvedSchedule H
EXCRETION
—
not curated
INTERACTIONS
8 major
SEVERE in our sources
PREGNANCY
and until their baby is one year old, or
FDA category + note
Top interactionssee all 8 →
- BurosumabSevereDatabaseDDInter
- CalcifediolSevereDatabaseDDInter
- CalcitriolSevereDatabaseDDInter
- CholecalciferolSevereDatabaseDDInter
Mechanism
Dihydrotachysterol (DHT) is a reduced form of vitamin D2. In the liver, DHT is converted to its active form, 25-hydroxydihydrotachysterol. This active form is much more effective in mobilizing bone mineral at high doses than calcitriol, allowing it to maintain plasma calcium concentrations in hypoparathyroidism.
Indications
Acute, chronic, and latent forms of hypocalcaemic tetany due to hypoparathyroidismMaintenance of plasma Ca2+ in hypoparathyroidismhypoparathyroidismfamilial hypophosphatemiaosteoporosissecondary hyperparathyroidism in patients with chronic kidney disease (CKD)Renal bone disease
Dosing
- Adult
- individuals, ergocalciferol or colecalciferol daily by mouth may be given to treat vitamin D deficiency; higher doses may be necessary for severe deficiency. Patients who do not respond should be referred to a specialist. Preparations containing colecalciferol with calcium carbonate p.…
Pharmacokinetics
Onset
faster than vitamin D
Peak effect
Maximally increases serum calcium concentration after 2 weeks of daily administration
Bioavailability
Well absorbed from the GI tract
Protein binding
lower affinity of metabolites for vitamin D–binding protein
Metabolism
Converted in the liver to its active form, 25-hydroxydihydrotachysterol
Side effects
Serious
- Abdominal cramps
- apathy
- dehydration
- hypertension
- paralysis
- renal failure
- stupor
- urinary disorders
- vertigo
- hypercalcemia
- hypercalciuria
- hyperphosphatemia
Pregnancy & lactation
Pregnancy
and until their baby is one year old, or
Drug interactions
Calcifediol
Severe
Database
Clinical effect not specified
Source: DDInter
Calcitriol
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Cholecalciferol
Severe
Database
Clinical effect not specified
Source: DDInter
Doxercalciferol
Severe
Database
Clinical effect not specified
Source: DDInter
Erdafitinib
Severe
Database
Clinical effect not specified
Source: DDInter
Ergocalciferol
Severe
Database
Clinical effect not specified
Source: DDInter
Paricalcitol
Severe
Database
Clinical effect not specified
Source: DDInter
4 additional low-confidence interactions hidden — those rows lack a documented mechanism or management plan in our sources.
Related guidelines
Chronic kidney disease — assessment and management
KDIGO · Nephrology · 2024
Acute kidney injury
KDIGO · Nephrology · 2012
Chronic kidney disease — assessment and management
NICE · Nephrology · 2021
Diabetes management in chronic kidney disease
KDIGO · Nephrology · 2022
Acute coronary syndrome in chronic kidney disease
CSI · Cardiology · 2020
Other Vitamin drugs
Ask House about Dihydrotachysterol
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, BNF·Verified: 2026-05-13 · House clinical team