Drug reference
droxidopa
Synthetic prodrug of norepinephrine · Vasopressor
Synthetic prodrug of norepinephrineVasopressorATC N07BC02
CDSCO approvedATC N07BC02
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Droxidopa is a synthetic prodrug that is converted by L-aromatic amino acid decarboxylase into norepinephrine, which then mediates its pharmacological effects.
Indications
orthostatic dizzinesslight-headedness (in adults with symptomatic neurogenic orthostatic hypotension associated with primary autonomic failure and impaired compensatory autonomic reflexes)
Pharmacokinetics
Protein binding
crosses the blood-brain barrier (presumably via amino acid transporter)
Metabolism
converted to norepinephrine by L-aromatic amino acid decarboxylase
Drug interactions
12 additional unreviewed or low-confidence interactions hidden because their provenance or source detail is insufficient.
Related guidelines
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Textbook-sourced·Sources: Goodman & Gilman 14e·Updated: 2026-05-10