Drug reference

glasdegib

hedgehog pathway inhibitor · Antineoplastic agent

hedgehog pathway inhibitorAntineoplastic agent

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

12 major

incl. contraindicated

PREGNANCY

FDA category + note

Top interactionssee all 12 →

PregnancyContraindicatedTextbookG&G 14e · p1390
AmiodaroneSevereDatabaseDDInter
AmisulprideSevereDatabaseDDInter
AnagrelideSevereDatabaseDDInter

Mechanism

Glasdegib is a hedgehog pathway inhibitor.

Indications

newly diagnosed acute myelocytic leukemia (AML) in patients 75 years of age or older (in combination with low-dose cytarabine) if comorbidities preclude use of intensive induction chemotherapy

Pharmacokinetics

Half-life

17.4 h (mean elimination)

Bioavailability

77% (oral)

Metabolism

CYP3A4

Side effects

Serious

QTc prolongation

Pregnancy & lactation

Pregnancy

Drug interactions

Pregnancy

Contraindicated

Textbook

Embryo-fetal death and severe birth defects.

The text implies avoidance during pregnancy, similar to vismodegib.

Source: G&G 14e · p1390

Amiodarone

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Amisulpride

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Anagrelide

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Apalutamide

Severe

Database

Drug interaction classified as: metabolism

Source: DDInter

Arsenic Trioxide

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Atazanavir

Severe

Database

Drug interaction classified as: metabolism

Source: DDInter

Bedaquiline

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Bepridil

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Boceprevir

Severe

Database

Drug interaction classified as: metabolism

Source: DDInter

Bosentan

Severe

Database

Drug interaction classified as: metabolism

Source: DDInter

Cabozantinib

Severe

Database

Drug interaction classified as: synergy

Source: DDInter

Related guidelines

Initial monotherapy for newly diagnosed epilepsy

IAN · Neurology · 2023

Initial monotherapy for newly diagnosed epilepsy

ILAE · Neurology · 2013

Induction of labour

FOGSI · Obstetrics & Gynaecology · 2019

Heart failure in diabetes

RSSDI · Cardiology · 2023

Breast cancer

ICMR · Oncology · 2022

Other hedgehog pathway inhibitor drugs

sonidegib

0 brands

Ask House about glasdegib

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Sources: Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team