Pregnancy
Contraindicated
Textbook
Embryo-fetal death and severe birth defects.
The text implies avoidance during pregnancy, similar to vismodegib.
Source: G&G 14e · p1390
Drug reference
sonidegib
hedgehog pathway inhibitor · Antineoplastic agent
hedgehog pathway inhibitorAntineoplastic agent
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
incl. contraindicated
PREGNANCY
X
FDA category + note
Top interactionssee all 12 →
- PregnancyContraindicatedTextbookG&G 14e · p1390
- AmprenavirSevereDatabaseDDInter
- ApalutamideSevereDatabaseDDInter
- AprepitantSevereDatabaseDDInter
Mechanism
Sonidegib is a hedgehog pathway inhibitor that binds to and inhibits SMO signal transduction similar to vismodegib.
Indications
locally advanced BCC that has recurred following surgery or radiation therapymetastatic or advanced BCC that has recurred after local therapy and who are not candidates for surgery or RT
Pharmacokinetics
Half-life
approximately 28 days
Bioavailability
less than 10% (oral)
Metabolism
CYP3A (predominantly)
Pregnancy & lactation
Pregnancy
X
Drug interactions
Amprenavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Apalutamide
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Aprepitant
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Atazanavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Berotralstat
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Boceprevir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Bosentan
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Carbamazepine
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Cenobamate
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Ceritinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Ciprofloxacin
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Related guidelines
Other hedgehog pathway inhibitor drugs
Ask House about sonidegib
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: Goodman & Gilman 14e, Harrison 22e·Verified: 2026-05-10 · House clinical team