Sildenafil
Contraindicated
Textbook
Severe hypotension, myocardial infarction, and deaths.
Glyceryl trinitrate should not be administered if the patient has taken sildenafil in the past 24 hours.
Source: KDT 7e · p542
Drug reference
glyceryl trinitrate
Drug monograph
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
1 major
incl. contraindicated
PREGNANCY
—
not curated
Top interactionssee all 2 →
- SildenafilContraindicatedTextbookKDT 7e · p542
Mechanism
Not yet extracted
Indications
relieves angina pectorisrapid relief in acute left ventricular failure (particularly that due to myocardial ischaemia/infarction)dilated cardiomyopathy (when CVP is raised)Hypertensive emergencies (especially with associated MI or LVF)Lowering BP after cardiac surgeryAcute LVFMIUnstable angina
Dosing
- Adult
- i.v. infusion (5–20 μg/min)
Pharmacokinetics
Onset
2–5 min
Duration
brief titratable action
Bioavailability
Glyceryl trinitrate exhibits high first-pass metabolism.
Protein binding
Glyceryl trinitrate is administered via transdermal drug delivery systems (patches, strips, or ointment) to prolong drug action.
Contraindications
- Standing still after sublingual administration
Side effects
Common
postural hypotensionthrobbing headachenitrate tolerance
Drug interactions
Vasodilators
Moderate
Textbook
Additive hypotension.
Source: KDT 7e · p542
Related guidelines
Other Unclassified drugs
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Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team