glycopyrrolate

Structurally unrelated to belladonna alkaloids. As a quaternary amine, it is less likely to cause adverse CNS effects as it is unable to cross the blood-brain barrier. Reduces sweating locally by inhibiting M3 receptors at eccrine sweat glands.

Adult

Oral: 1 to 2 mg two or three times daily, not to exceed 6 mg/day.

Pediatric

5–10 µg/kg i.m.

• Urinary tract obstruction
• GI obstruction
• Uncontrolled angle-closure glaucoma
• Benign prostatic hyperplasia (use with extreme caution)
• Colitis
• Reflux esophagitis
• Bowel obstruction