Drug reference

isoproterenol

Potent nonselective β adrenergic receptor agonist · Cardiostimulant, Bronchodilator

Potent nonselective β adrenergic receptor agonistCardiostimulant, BronchodilatorATC C01CA02

CDSCO approvedATC C01CA02

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Isoproterenol is a potent nonselective β adrenergic receptor agonist with very low affinity for α receptors. It lowers peripheral vascular resistance, decreases diastolic pressure, and increases cardiac output due to positive inotropic and chronotropic effects. It relaxes almost all varieties of smooth muscle, notably bronchial and GI smooth muscle, preventing bronchoconstriction.

Indications

stimulate heart rate in patients with bradycardia or heart block (emergencies)ventricular arrhythmia torsades de pointes (emergencies)asthma (largely replaced by other drugs)shock (largely replaced by other drugs)Bronchodilation (as last resort)