Drug reference

lugol solution

ionic inhibitor, antithyroid drug (iodine preparation) · antithyroid, radiation protection

ionic inhibitor, antithyroid drug (iodine preparation)antithyroid, radiation protection

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Consists of 5% iodine and 10% potassium iodide, yielding about 8 mg of iodine per drop. Provides iodide that acutely reduces the secretion and synthesis of thyroid hormone.

Indications

preoperative period in preparation for thyroidectomyin conjunction with antithyroid drugs and propranolol in the treatment of thyrotoxic crisisprotection from radioactive iodine fallout

Dosing

Adult: 16 to 36 mg (2–6 drops) three times a day.

Contraindications

pregnancy

Side effects

Common

iodism (unpleasant brassy taste, burning in the mouth and throat, soreness of the teeth and gums, increased salivation, coryza, sneezing, irritation of the eyes with swelling of the eyelids, mild iodism simulates a "head cold", enlarged and tender parotid and submaxillary glands, skin lesions, gastric irritation, diarrhea, fever, anorexia, depression)

Serious

angioedema
laryngeal edema (may lead to suffocation)
multiple cutaneous hemorrhages
serum sickness type of hypersensitivity (fever, arthralgia, lymph node enlargement, eosinophilia)
thrombotic thrombocytopenic purpura
fatal periarteritis nodosa
severe and sometimes fatal eruptions (ioderma)