Almotriptan
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Drug reference
methysergide
Ergot alkaloid · Antimigraine
Ergot alkaloidAntimigraine
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
12 major
SEVERE in our sources
PREGNANCY
—
not curated
Top interactionssee all 12 →
- AlmotriptanSevereDatabaseDDInter
- AmprenavirSevereDatabaseDDInter
- AtazanavirSevereDatabaseDDInter
- BoceprevirSevereDatabaseDDInter
Mechanism
Not yet extracted
Indications
Acute treatment of migraine (restricted to patients with frequent, moderate, or infrequent, severe attacks)Treatment of vascular headaches
Pharmacokinetics
Bioavailability
Erratic drug absorption
Side effects
Serious
- Inflammatory fibrosis with prolonged use
- Pleuropulmonary fibrosis
- Endocardial fibrosis
Drug interactions
Amprenavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Atazanavir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Boceprevir
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Bromocriptine
Severe
Database
Drug interaction classified as: synergy
Source: DDInter
Ceritinib
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Clarithromycin
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Cobicistat
Severe
Database
Drug interaction classified as: metabolism
Source: DDInter
Darunavir
Severe
Database
Clinical effect not specified
Source: DDInter
Delavirdine
Severe
Database
Clinical effect not specified
Source: DDInter
Dihydroergotamine
Severe
Database
Clinical effect not specified
Source: DDInter
Dopamine
Severe
Database
Clinical effect not specified
Source: DDInter
Related guidelines
Other Ergot alkaloid drugs
Ask House about methysergide
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e·Verified: 2026-05-10 · House clinical team