Drug reference

ergotoxine

Ergot alkaloid · Antiadrenergic

Ergot alkaloidAntiadrenergic

CDSCO approved

EXCRETION

—

not curated

INTERACTIONS

—

none in our sources

PREGNANCY

—

not curated

Mechanism

Ergotoxine is a partial agonist and antagonist at α adrenergic, serotonergic, and dopaminergic receptors. It is a more potent α blocker and less potent vasoconstrictor than ergotamine.

Indications

Migraine

Related guidelines

Migraine — preventive therapy

AAN · Neurology · 2015

Functional (psychogenic non-epileptic) seizures

AAN · Neurology · 2026

Painful diabetic peripheral neuropathy

AAN · Neurology · 2022

Status epilepticus

AAN · Neurology · 2020

Primary headache disorders

NICE · Neurology · 2021

Other Ergot alkaloid drugs

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Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team