Ergot alkaloid · Antiadrenergic
Ergotamine is a partial agonist and antagonist at α adrenergic, serotonergic, and dopaminergic receptors.
Increased risk of serious vasoconstrictive adverse effects, including coronary vasospasm and myocardial infarction.
Do not administer sumatriptan and ergotamine within 24 hours of each other.
Source: KDT 7e · p179
Ergotism: severe peripheral vasospasm, ischemia of extremities, gangrene
Absolutely contraindicated. Use alternative antibiotic or alternative migraine therapy
Source: DDInter
Ergotism
Contraindicated.
Source: DDInter
Ergotism: severe peripheral vasospasm, gangrene
Never combine. Use alternative migraine therapy.
Source: DDInter
Increased plasma concentrations of ergotamine, leading to ergotism (vasospasm, ischemia of extremities and other tissues).
Concomitant use is contraindicated due to the risk of severe and potentially life-threatening vasospasm. Avoid completely.
Rise in plasma levels of ergotamine.
Source: KDT 7e · p753
Increased plasma concentrations of ergot alkaloids, leading to ergotism (vasospasm, ischemia of extremities).
Avoid co-administration. If unavoidable, monitor closely for signs of ergotism. Consider alternative treatments.
Source: DDInter
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team