Ergot alkaloid · Antiadrenergic
Ergotamine is a partial agonist and antagonist at α adrenergic, serotonergic, and dopaminergic receptors.
Increased risk of serious vasoconstrictive adverse effects, including coronary vasospasm and myocardial infarction.
Do not administer sumatriptan and ergotamine within 24 hours of each other.
Source: KDT 7e · p179
Ergotism: severe peripheral vasospasm, ischemia of extremities, gangrene
Absolutely contraindicated. Use alternative antibiotic or alternative migraine therapy
Source: DDInter
Ergotism
Contraindicated.
Source: DDInter
Ergotism: severe peripheral vasospasm, gangrene
Never combine. Use alternative migraine therapy.
Source: DDInter
Rise in plasma levels of ergotamine.
Source: KDT 7e · p753
Increased plasma concentrations of ergot alkaloids, leading to ergotism (vasospasm, ischemia of extremities).
Avoid co-administration. If unavoidable, monitor closely for signs of ergotism. Consider alternative treatments.
Source: DDInter
1 additional unreviewed or low-confidence interaction hidden because their provenance or source detail is insufficient.
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Textbook-sourced·Sources: KD Tripathi 7e·Updated: 2026-05-10