Drug reference
mitomycin c
Antibiotic · Anticancer
AntibioticAnticancer
CDSCO approved
EXCRETION
—
not curated
INTERACTIONS
—
none in our sources
PREGNANCY
—
not curated
Mechanism
Mitomycin C is transformed intracellularly into a form that acts as an alkylating agent, cross-linking DNA. It also generates free radicals that damage DNA. It is a cell cycle specific drug acting in S phase.
Indications
Resistant cancers of stomach, cervix, colon, rectum, breastSuperficial bladder tumours (intravesical instillation)
Side effects
Common
Bone marrow toxicityG.i.t. toxicityMyelosuppression (typically delayed)
Serious
- Haemolytic-uremic syndrome
Related guidelines
Other Antibiotic drugs
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Sources: KD Tripathi 7e·Verified: 2026-05-10 · House clinical team