Opioid Analgesic · Alcohol dependence management
Also known as Nalmefene hydrochloride
Nalmefene is an opioid receptor antagonist, modulating the opioid system. This action helps to reduce alcohol consumption in dependent patients.
Blocks the analgesic effects of opioid analgesics. Can precipitate severe withdrawal symptoms in an opioid-dependent patient.
Naltrexone is contraindicated in patients taking opioids concurrently. If opioid analgesics are needed for pain management, higher doses may be required and should be administered under strict medical supervision after considering the risks.
Source: G&G 14e · p527, p528, p529
Acetaminophen-related hepatotoxicity, a significant cause for liver failure.
Many practitioners have moved away from opioid-acetaminophen combination analgesics to avoid the risk of excessive acetaminophen exposure.
Source: Harrison 22e · p98-99
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Exaggerated CNS depression.
Source: KDT 7e · p401
Marked depression of respiration, cardiac contractility, and blood pressure.
Carefully monitor respiratory and cardiovascular functions when co-administering benzodiazepines with opioids due to increased risk of severe depression of vital signs.
Source: KDT 7e · p383
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Increased rates of accidental overdose and death.
Caution is advised, especially for patients with a history of drug abuse.
Source: G&G 14e
Increased number of deaths.
Avoid combination due to increased risk of respiratory depression and death.
Source: G&G 14e
Continue into a citation-backed clinical answer with the drug context already attached.
Sources: KD Tripathi 7e, Goodman & Gilman 14e, Katzung, BNF·Verified: 2026-05-10 · House clinical team