Drug reference

Hydrocodone

Opioid Analgesic · Analgesic, Antitussive

Also known as Lorcet, HYCODAN

Opioid AnalgesicAnalgesic, Antitussive

CDSCO approvedSchedule X

EXCRETION

—

not curated

INTERACTIONS

12 major

SEVERE in our sources

PREGNANCY

—

not curated

Top interactionssee all 12 →

BarbituratesSevereTextbookKDT 7e · p401
BenzodiazepinesSevereTextbookKDT 7e · p383
Chlordiazepoxide HydrochlorideSevereTextbookG&G 14e
ClomethiazoleSevereTextbookG&G 14e

Mechanism

Hydrocodone is an opioid drug. It functions as an analgesic for pain relief and as an antitussive for cough suppression. The drug undergoes metabolism primarily via the cytochrome P450 2D6 (CYP2D6) isoenzyme system.

Indications

AnalgesiaAntitussivemoderate-to-severe paincough suppressantAnalgesic

Dosing

Adult: 302 (41–133),* alanine aminotransferase (ALT) 351 (7–56),* aspartate aminotransferase (AST) 1045 (0–35),* bilirubin 3.33 mg/dL (0.1–1.2),* and. the normal value at her age, elevated serum creatinine, and blood urea nitrogen, markedly reduced blood glucose of 35 mg/dL, and a plasma.…
Pediatric: Oral: 0.1 mg/kg/3–4 h

Pharmacokinetics

Duration

4–6 h

Half-life

4 h

Bioavailability

—

Protein binding

—

Metabolism

Metabolized by CYP2D6

Excretion

EM: 10.2 ± 1.8%; PM: 18.1 ± 4.5%

Contraindications

Urinary tract obstruction
GI obstruction
Uncontrolled angle-closure glaucoma
Susceptibility to attacks of angle-closure glaucoma
Benign prostatic hyperplasia (use with extreme caution)
Combined with CNS depressants

Side effects

Common

XerostomiaConstipationBlurred visionDyspepsiaCognitive impairmentHistamine releaseItchingSimilar side effects to oxycodone

Serious

Disorientation (overdose)
Midsternal chest pain (overdose)
Abdominal pain (overdose)
Shaking (overdose)
Vomiting (overdose)
Abnormal liver function (increased alkaline phosphatase, ALT, AST, bilirubin, prothrombin time) (overdose)
Reduced glomerular filtration rate (overdose)
Elevated serum creatinine (overdose)
Elevated blood urea nitrogen (overdose)
Markedly reduced blood glucose (overdose)

Drug interactions

Barbiturates

Severe

Textbook

Exaggerated CNS depression.

Source: KDT 7e · p401

Benzodiazepines

Severe

Textbook

Marked depression of respiration, cardiac contractility, and blood pressure.

Carefully monitor respiratory and cardiovascular functions when co-administering benzodiazepines with opioids due to increased risk of severe depression of vital signs.

Source: KDT 7e · p383

Chlordiazepoxide Hydrochloride

Severe

Textbook

Increased rates of accidental overdose and death.

Caution is advised, especially for patients with a history of drug abuse.

Source: G&G 14e

Clomethiazole

Severe

Textbook

Increased rates of accidental overdose and death.

Caution is advised, especially for patients with a history of drug abuse.